Searchable abstracts of presentations at key conferences on calcified tissues

ba0007oc26 | (1) | ICCBH2019

[18F] NaF PET/CT the first tool to diagnose chronic activity in FOP at all ages?

Netelenbos Coen , Botman Esmee , Raijmakers Pieter GHM , Lammertsma Adriaan A , Eekhoff Marelise W

Fibrodysplasia ossificans progressiva (FOP) is a rare, autosomal dominant disorder characterized by heterotopic ossification (HO) in muscles, ligaments and tendons. Flare-ups often precede formation of HO, resulting in immobilized joints. Recently, it has been shown that [18F]NaF PET/CT could identify early ossifying disease activity during flare-ups. HO may progress without signs of flare-up, but its underlying physiology is not understood. We wondered whether [18F]NaF PET/CT...

ba0005p197 | Cell biology: osteoclasts and bone resorption | ECTS2016

Effects of TGF-β inhibition on osteogenesis and osteoclastogenesis by periodontal ligament fibroblasts from patients with fibrodysplasia ossificans progressiva

de Vries Teun J. , Schoenmaker Ton , Micha Dimitra , Netelenbos Coen , Pals Gerard , Eekhoff Marelise W. , Bravenboer Nathalie

Background: Fibrodysplasia Ossificans Progressiva (FOP) is a progressive disease characterized by periods of heterotopic ossification, often in ligaments. The underlying mechanism is far from clear, partially due to limited access to patient-derived cell models. Periodontal ligament fibroblasts (PLF) from extracted teeth can potentially be used to study deviant bone remodelling processes in vitro since these cells are derived from actual ligaments. They further provid...